The ready-to-use BabyBio™ TREN columns are prepacked with WorkBeads™ 40 TREN resin and are available in two column sizes, 1 ml and 5 ml. WorkBeads 40 TREN resin for multimodal Ion Exchange Chromatography (IEX) has a ligand which is positively charged below approx. pH 9. The resin can be used for several different applications, particularly due to its higher salt tolerant properties, e.g., for multimodal IEX, for sample cleanup in monoclonal antibody (mAb) purification processes in order to guard the Protein A column from chromatins and other host cell impurities, or as a polishing step
in the mAb purification process.
- Differential selectivity due to higher salt tolerance and multimodal properties
- Improved selectivities through multimodal IEX separation
- Reduced fouling of Protein A resins by chromatin and host cell impurity removal
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