HMDS should be used in addition of catalytic quantities of TMCS (e.g., 1 %) or as a mixture with TMCS (2 -1, v/v; SILYL-21 and SILYL-2110), because after that it is a fast and quantitative reagent for silylation. These products contain harmful substances which must be specially labeled as hazardous. For detailed information please see SDS.
| Hazardous material | Yes |
| Method | Gas chromatography (GC), derivatization |
| Composition | Hexamethyldisilazane (HMDS) |
| Derivatization type | Silylation |
| Recommended application(s) | Acetonitrile, Aprotic solvents, Carbon disulfide, Derivatization, Dimethylacetamide, Dimethylformamide, Organic compounds, Pyridine |
| Storage temperature | 2–8 °C |